Traffic, sports or work accidents can lead to severe damage of the spinal cord and brain with subsequent impairments of standing, walking or arm and hand movements as well as sensory and cognitive deficits. Tragically, many of these deficits persist lifelong. This is due to the poor repair capacity of the central nervous system. An important player for this restricted repair is a protein of the brain and spinal cord, Nogo-A, which inhibits nerve fiber growth and regeneration.
Recent research has characterized the protein Nogo-A and its mechanism of action in great detail and has found ways to block Nogo-A’s actions with function blocking antibodies. NovaGo’s approaches are built on this knowledge base.
